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Saying a brand new publication for Acta Materia Medica journal. Immune checkpoint inhibitors (ICIs) have revolutionized most cancers therapy however pose a problem of immune-related antagonistic occasions (irAEs), significantly endocrine toxicity, that may severely compromise affected person well-being. Present analysis has typically been restricted in scope and has not supplied complete security profiles throughout the various vary of ICI therapies.

The authors of this text handle this hole by performing a community meta-analysis on 55 randomized managed trials involving 32,522 sufferers. Utilizing STATA to calculate the floor beneath the cumulative rating curve, we ranked the protection of varied ICI monotherapies and mixture therapies. ICIs have been discovered to extend the danger of endocrine toxicities, reminiscent of hypothyroidism, hyperthyroidism, hypophysitis, thyroiditis, and adrenal insufficiency; this threat was better with twin ICI regimens. Particularly, cytotoxic T lymphocyte related antigen-4 (CTLA-4) inhibitors, reminiscent of ipilimumab, are intently related to hypophysitis, whereas programmed cell death-1 (PD-1)/programmed cell dying ligand-1 (PD-L1) inhibitors, notably pembrolizumab and nivolumab, predispose sufferers to thyroid-related dysfunction, reminiscent of hyperthyroidism, hypothyroidism, and thyroiditis. Curiously, nivolumab confirmed no elevated threat of adrenal dysfunction, in distinction to the elevated threat noticed with different ICI therapies.

This examine supplies vital evidence-based insights for optimizing the risk-benefit steadiness of ICI therapies in medical observe.

 

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Journal reference:

Ouyang, P., et al. (2024) Endocrine toxicity of immune checkpoint inhibitors: a community meta-analysis of the present proof. Acta Materia Medica. doi.org/10.15212/AMM-2023-0037.

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