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Wrong, counterintuitive

For years, many have struggled to know why some dietary dietary supplements, elements of meals, even medication clearly exerted useful well being results—however weren’t absorbed by the gastrointestinal (GI) tract). Some compounds with substantial well being advantages are fully inert in people, ingested after which flushed down the bathroom.

Take curcumin, for instance. This part of the spice, turmeric, taken orally is nearly fully unabsorbed. Should you took 100 mg of curcumin, 99 mg or so is undigested, unprocessed, unmetabolized by your GI digestive course of and handed out in a bowel motion. But the proof is evident: curcumin reduces measures of irritation comparable to C-reactive protein, reduces arthritis ache, and exerts metabolic advantages comparable to decreased blood sugar and triglycerides. Many efforts have due to this fact been made to attempt to pressure absorption of curcumin to extend efficacy: mixed with piperine, bioperine, nanoparticle emulsions, surfactants, chelating brokers, and others. Absorption can certainly be elevated, although nobody has but demonstrated a rise in useful results with enhanced absorption.

Think about this: Curcumin has additionally been proven to extend intestinal mucus manufacturing and the intestinal immune response, explaining why curcumin, working inside the GI tract, improves the intestinal barrier to entry of bacterial breakdown merchandise. This may occasionally clarify why curcumin has been proven to cut back endotoxemia, i.e., the entry of bacterial lipopolysaccharide toxin into the bloodstream, explaining why curcumin reduces body-wide irritation, reduces measures of irritation like C-reactive protein, reduces arthritis ache, and improves metabolic measures comparable to blood sugar and triglycerides. Curcumin additionally modifies bacterial species composition of intestine flora, decreasing fecal species of Proteobacteria (e.g., E. coli, Klebsiella, and different fecal microbes) and Enterococcus. Do you see the place I’m going with this? If curcumin is understood to exert essential results inside the GI tract, then perhaps you do NOT wish to pressure absorption and also you need most focus inside the intestines, not within the bloodstream.

There are different compounds which have useful results but are poorly-absorbed or not absorbed in any respect, comparable to:

  • Berberine—Exerting lots of the similar advantages as curcumin however with larger antibacterial and antifungal results. It additionally boosts Akkermansia numbers within the GI tract, a serious determinant of metabolic well being.
  • Inexperienced tea catechins—Related to weight reduction, discount of tension, improved cognitive perform, and different useful results. Inexperienced tea catechins are identified to crosslink mucin proteins inside intestinal mucus, changing it to a much less liquid to a extra gel-like, much less penetrable, consistency.
  • Capsaicin—That is the part of peppers that’s liable for the new feeling within the mouth. Capsaicin helps “mildew” the microbial composition of bowel flora rising, as an illustration, essential species comparable to Faecalibacterium prausniztrii, the principle producer of butyrate that mediates a protracted checklist of well being advantages for people.
  • Quercetin—Quercetin is a flavonoid sourced from meals comparable to apples, onions, broccoli, and inexperienced tea. Whereas plenty of essential well being advantages have been documented, quercetin could also be particularly useful in enhancing insulin responses and decreasing blood sugar, although there may be minimal absorption.

You’ll be able to recognize that there was numerous wasted effort in attempting to plot methods to extend absorption, when the actual advantages could derive from NOT being absorbed and exerting results on the GI microbiome, the intestinal mucus and immune limitations, and endotoxemia. You may also recognize that there’s a lot of selling occurring to advertise gross sales of variations of, say, curcumin, with enhanced absorption that will show to be much less efficient than non-absorbable varieties. It highlights the large position that the GI microbiome and GI tract play in quite a few human well being circumstances. In a future weblog put up, I shall focus on all of the methods which you can simply, safely, inexpensively, successfully benefit from methods that enhance your GI intestinal barrier and cut back endotoxemia to acquire enormous well being advantages and ignore numerous pointless or deceptive advertising and marketing efforts.



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